KING-UNDERWOOD, JOHN,HARDY, GEORGE,MURRAY, PETER JOHN,WILLIAMS, JONATHAN GARETH,ONIONS, STUART THOMAS
申请号：
ES11713510
公开号：
ES2532764T3
申请日:
2011.04.01
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound of formula (I): ** Formula ** in which, R1 is H, phenyl, or a linear or branched C1-10 alkylene or cyclic chain, saturated or unsaturated, in which one or more carbons in the chain they are optionally replaced by one or more heteroatoms independently selected from O, N and S (O) n and the chain is optionally substituted with: an oxo group and / or one or more halogen atoms； R2a is H, halo, a C1-8 alkylene chain, saturated or unsaturated, branched or unbranched, in which one or more carbons are optionally replaced by one or more heteroatoms independently selected from O, N and S (O) m the chain is optionally substituted with one or more halogen atoms； R2b is H, halo, C1-6 alkoxy or C1-6 alkyl optionally substituted with OH； R3 is halo, haloalkyl, S (O) C1-6 alkyl or cyano； R4 is H, halo, haloalkyl, or cyano； or R3 and R4 taken together with the carbon atoms to which they are attached form: a carbocyclic ring, saturated or partially unsaturated of 5 to 6 members, or a heterocyclic ring of 5 to 6 members, saturated or partially unsaturated or unsaturated containing 1 or more heteroatoms independently selected from N, O and S； L is a C1-6 alkylene chain, saturated or unsaturated, branched or unbranched, in which one or more carbons are optionally replaced by a heteroatom selected from O and S, and the chain is optionally substituted with one or two oxo groups ； X is pyridine or pyrimidine optionally substituted with C1-3 alkyl or C1-3 haloalkyl； R5 is -H or C1-4 alkyl； R6 is selected from: a) a C1-10 alkyl chain, saturated or unsaturated, branched or unbranched, in which optionally at least one carbon is replaced by a heteroatom independently selected from O, N and S (O) p, wherein said chain is optionally substituted with one or more groups independently selected from oxo, halogen, a C6-10 aryl group, a 5 or 6 membered heteroaryl group, a 5 or 6 membered heterocyclyl group and a C3- cycloalkyl group 8, each aryl, heteroaryl, heterocyclyl or cycloalkyl bearin
