FIELD: medicine, pharmaceutics.SUBSTANCE: in general formula A1 stands for CR10R11 or S； A2 stands for CR12R13, C(=O), O, S or S(=O)2； R1 stands for C1-10-alkyl, saturated or unsaturated, branched or non-branched, non-substituted, or monosubstituted, or polysubstituted； C3-10-cycloalkyl or 5- or 6-membered heterocyclyl with the O-atom, each time saturated or unsaturated, non-substituted, or monosubstituted, or polysubstituted； C6-10-aryl or C5-10-heteroaryl with 1-3 heteroatoms, selected from N, O or S, each time non-substituted, or monosubstituted, or polysubstituted； through C1-8-alkyl or C2-8-heteroalkyl bound by the bridge bond C3-10-cycloalkyl, each time saturated, non-substituted, and the alkyl or heteroalkyl chain each time can be branched or non-branched, saturated, non-substituted； or through C1-8-alkyl, bound by the bridge bond aryl or heteroaryl, each time non-substituted, or monosubstituted, or polysubstituted, and the alkyl chain each time can be branched or non-branched, saturated or unsaturated, non-substituted, or monosubstituted, or polysubstituted； R2, R3 and R4 each time independently on each other stand for H； F； Cl； Br； I； methyl； O-C1-6-alkyl or NRaRb, and Ra and Rb together with the nitrogen atom that binds them form heterocyclyl, saturated, non-branched, non-substituted； R5, R6, R7, R8, R10, R11, R12 and R13each time independently on each other stand for H； F； Cl； Br； I； OH or C1-10-alkul； or R5 and R6 or R7 and R11 together with carbon atom(s), that bind(s) them form C3-8-cycloalkyl, each time saturated or non-saturated, non-substituted, or monosubstituted, or polysubstituted； with respective remaining substituents R5, R6, R7, R8, R10, R11, R12 and R13 having the value given above； R9 stands for C3-10-cycloalkyl, saturated, non-substituted； C6-10-aryl or 5- or 6-membered heteroaryl with heteroatom, selected from N and S, each time non-substituted or monosubstituted.EFFECT: invention relates to substituted nicotinamides of general formula (1
