The invention relates to a humanized form of an antibody capable of preventing tissue factor (coagulation factor F3) signaling but which does not interfere with Factor VII binding or FX binding to tissue factor and does not prolong coagulation time. The antibody of the invention is useful in treating conditions, such as tumor progression, in which the associated cells express tissue factor and tissue factor signaling occurs.本發明是關於一種人類型抗體,其能夠避免組織因子(凝血因子F3)訊息傳遞,但不會防礙對組織因子的因子VII結合和FX結合且不會延長凝血時間。本發明的抗體係用於治療,例如腫瘤進展的症狀,其中相關細胞會表現組織因子且組織因子訊息傳遞發生。