針對血小板衍生生長因子受體-α（ＰＤＧＦＲ-α）之致標性結合劑及其用途农业专利-农业学术服务平台

发明人:: FOLTZ, IAN,佛特兹　艾恩,佛特茲　艾恩,LAING, NAOMI,梁　娜欧密,梁　娜歐密,KANG, JASPAL SINGH,康　贾斯伯Ｓ.,康　賈斯伯Ｓ.,GAZIT-BORNSTEIN, GADI,葛兹特　波史崔　葛迪,葛茲特　波史崔　葛迪,YANG, XIAO-DANG,杨小丹,楊小丹,CARTLIDGE, SUE A.,卡特李吉　苏Ａ.,卡特李吉　蘇Ａ.,BLAKEY, DAV,佛特兹艾恩,佛特茲艾恩,梁娜欧密,梁娜歐密,康贾斯伯S.,康賈斯伯S.,葛兹特波史崔葛迪,葛茲特波史崔葛迪,卡特李吉苏A.,卡特李吉蘇A.

摘要：: Targeted binding agents directed to the antigen PDGFR-alpha and uses of such agents are disclosed herein. More specifically the invention relates to fully human monoclonal antibodies directed to the antigen PDGFR-alpha and uses of these antibodies. Aspects of the invention also relate to hybridomas or other cell lines expressing such antibodies. The described targeted binding agents and antibodies are useful as diagnostics and for the treatment of diseases associated with the activity and/or overexpression of PDGFR-alpha.此處係揭露針對抗原PDGFR－α之致標性結合劑以及此類劑之用途。更特定地，本發明係關於針對抗原PDGFR－α之完全人類單株抗體以及此類抗體之用途。本發明之觀點亦關於表現此類抗體之融合瘤及其它細胞株。該所述之致標性結合劑及抗體係可使用於診斷及治療和PDGFR－α之活性及/或過度表現相關聯之疾病。