The present disclosure is directed to insect-resistant fabrics or garments and methods for making the same. The insect-resistant fabrics or garments include a combination of actives such as one or more insect repellants and an insecticide. As an example, an insect-resistant fabric in accordance with the disclosure can include a base fabric (e.g., polyester) having been treated to include an insect repellant (e.g., an essential oil) in a first region of the fabric, and an insecticide (e.g., permethrin) in second region of the base fabric. The combination of multiple actives which can have different modes of action is shown herein to provide improved insect-resistant efficacy. Additionally, certain insect-resistant fabrics disclosed herein can also demonstrate durability when exposed to wear such as laundering the garment.