A.N. Nesmeyanov Institute of Organoelement Compounds Russian Academy of Sciences (INEOS RAS)
发明人:
Pavel N. Kolesnikov,Denis A. Chusov,Oleg I. Afanas'ev,Victor I. Maleev
申请号：
RU20160103167
公开号：
RU2620269(C1)
申请日:
2016.02.02
申请国别(地区):
俄罗斯
年份:
2017
代理人:
摘要：
FIELD: chemistry.SUBSTANCE: method for preparing amides is carried out by reductive amidation of carbonyl compounds at elevated pressures and heated in the presence of a metal catalyst in a polar solvent, using as the reducing carbon monoxide. Instead of catalyst, salt or metal carbonyls are used. They are selected from the group consisting of rhodium, ruthenium, iridium, cobalt, iron. The molar ratio of amide carbonyl compound and the catalyst is (0.5-1.5):1.0:(0.005-0.05), it is preferably 1.5:1.0:0.01. As the solvent, tetrahydrofuran, acetonitrile, ethyl acetate, methylene chloride, alcohols are used. The process is carried out at a pressure of 5-150 atm and at a temperature of 30-250°C.EFFECT: technological and economical method for producing amides by reductive amidation of carbonyl compounds is suitable for use in industry.6 cl, 30 ex
