Disclosed is a compound of formula ( I ):crystalline forms thereof, and solvates thereof； pharmaceutical compositions comprising a pharmaceutically effective amount of the compound of formula ( I ), or a crystalline form thereof, or a solvate thereof, and a pharmaceutically acceptable carrier or diluent； and the use of a compound of formula ( I ), or a crystalline form thereof, or a solvate thereof, for treating a patient suffering from, or subject to, a pathological condition capable of being ameliorated by inhibiting an E1 activating enzyme, particularly NAE, including, e.g., cancer.
