BRUNCKO, MILAN,DING, HONG,DOHERTY, GEORGE A.,ELMORE, STEVEN W.,HASVOLD, LISA,HEXAMER, LAURA,KUNZER, AARON,MANTEI, ROBERT A.,MCCLELLAN, WILLIAM J.,PARK, CHEOLMIN,PETROS, ANDREW M.,SONG, XIAOHONG,SOUERS
申请号：
PE0007592012
公开号：
PE13852012A1
申请日:
2010.06.01
申请国别(地区):
PE
年份:
2012
代理人:
摘要：
Refers to sulfonamide compounds of formula (i) where A2, B1, D1 and E1 are each R1, OR1, SR1, S (or R1, among others) where R1, R2, R3, R4 and R5, where R2 is phenyl optionally merged with Sandy, heteroareno, among others R3 is optionally heteroaryl FUSED benzene Heteroareno, among others R4 is cicloalquenilo heterocicloalquilo cycloalkyl,,,Among others, alquenilo R5 is alkyl, or alquinilo y1 is H, F, NO2, CN, CF3, among others ocf3 R26, R27 Z1 is or where R26 is phenyl optionally merged with sandy or heteroareno heteroareno R27 is optionally merged with sandy or heteroareno.Preferred compounds are: 4 - ((4 - (4 - Chloro - 1,1 - biphenyl - 2 - yl) methyl) piperazin-1-yl) - N - ((3 - (4 - (nitro - tetrahydro - 2H - piran - 4 - methyl) amino) phenyl) sulfonyl) - 2 - fenoxibenzamida 4 - ((4 - (4 - Chloro - 1,1 - biphenyl - 2 - yl) methyl) piperazin-1-yl) - 2 - phenoxy - (N - (4 - ((Tetrahydro - 2H - piran - 4 - methyl) amino) phenyl] sulfonyl) Benza Measure 2 - (Benzyloxy) - 4 - ((4 - (4 - Chloro - 11 - biphenyl - 2 - yl) methyl) piperazin-1-yl) - N - ((3 - (4 - (nitro - tetrahydro - 2H - piran - 4 - methyl) amino) phenyl] sulfonyl) benzamide among others. It also relates to a Pharmaceutical composition. These compounds are inhibitors of the activity of the anti apoptotic Proteins bcl-2 being useful in the treatment of bladder cancer, Chronic Lymphocytic Leukemia, melanomaSE REFIERE A COMPUESTOS DERIVADOS DE SULFONAMIDA DE FORMULA (I) DONDE A2, B1, D1 Y E1 SON CADA UNO R1, OR1, SR1, S(O)R1, ENTRE OTROS, DONDE R1 ES R2, R3, R4 O R5, EN DONDE R2 ES FENILO OPCIONALMENTE FUSIONADO CON ARENO, HETEROARENO, ENTRE OTROS R3 ES HETEROARILO OPCIONALMENTE FUSIONADO CON BENCENO, HETEROARENO, ENTRE OTROS R4 ES CICLOALQUILO, CICLOALQUENILO, HETEROCICLOALQUILO, ENTRE OTROS R5 ES ALQUILO, ALQUENILO O ALQUINILO Y1 ES H, CN, NO2, F, CF3, OCF3, ENTRE OTROS Z1 ES R26 O R27, EN DONDE R26 ES FENILO OPCIONALMENTE FUSIONADO CON ARENO O HETEROARENO R27 ES HETEROARENO OPCIONALMENTE FUSIONADO CON
