PARK, CHEOL,MIN - PARK, CHANG H.,MCLELLAN, WILLIAM J.,MANTEI, ROBERT A.,KUNZER, AARON,HEXAMER, LAURA,HASVOLD, LISA,ELMORE, STEVEN W.,DOHERTY, GEORGE A.,DING, HONG,BRUNCKO, MILAN,HANSEN, TODD M.,WENDT,
申请号：
ARP190100089
公开号：
AR114083A2
申请日:
2019.01.17
申请国别(地区):
AR
年份:
2020
代理人:
摘要：
1. Compounds that inhibit the anti doomsday protein activity of Bcl-2 or Bcl-xL, including their components, and compounds used to treat various cancers including leukemia. 1. Claim 1: a compound with formula characteristics (1),Or a therapeutically acceptable salt, Prof or Prof á mico salt, A1 being n or C (A2)；1、 Two, three, or every year,B1，D1 and E1 are selected independently between R1Or1，SR1，S（O）R1，SO8322；R1，C（O）R1，C（O）Or1，OC（O）R1，NHR1，N（R1）832222，c（o）NHR1，c（o）n（r1）832222，NHC（O）R1，NHC（O）Or1，NHROC（O）NHR1，NR1（O）N（R1）8322；SO83228NHR1，SO8322；（R1）8322；NHSO83228R1，NHSSO 8322；（NHR1 o N（CH832323）SO 8322；n（CH 83223）R1，The rest were selected independently from h, F, Cl, Br, I, CN, cf832323.c（o）o h，c（o）NH 83222 o C（o）Or1；Y 1 es H，CN，no 832222；c（o）Oh，F，CL，BR，I，CF832323；OCF83223，CF8322；CF83323；OCF83228CF8323，R18311，Or18311，c（o）R18311，c（o）Or°8311；Sr.18311，NH.8322；NHR1 8311；n（R831111）8322；NHC（O）R18311；c（o）NH832222；c（o）NHR1 8311；c（o）n（R183118311）8322；NHS（O）R18311O NHSO83222；R1 8311；Or B1 and Y1,Plus the atoms they're attached to, they're pyridazole or triazole, and they're one, two, three years old,D1 and E1 are selected independently between R1Or1，SR1，S（O）R1，SO8322；R1，C（O）R1，C（O）Or1，OC（O）R1，NHR1，N（R1）832222，c（o）NHR1，c（o）n（r1）832222，NHC（O）R1，NHC（O）Or1，NHC（O）NHR1，n（ch8323）c（o）n（ch832323）r1，SO83228NHR1，SO8322；（R1）8322；NHSO83228R1，NHSSO 8322；（NHR1 o N（CH832323）SO 8322；n（CH 83223）R1，The rest were selected independently from h, F, Cl, Br, I, cf832323.c（o）oh，c（o）NH 832222 o C（o）Or1；r1 is r2，R3，R8308O R830909；R2 is c8332131832626 tar, c833238331832626 asphalt； R2 is phenyl, not mixed with or combined with herring, isoherring or R2； R2 is cyclopropane or isocyclopropane； R3 is non propylene, not combined with benzene, isoherring or R3； R3 is isopropene, not combined with benzene, isopropene or R3； R3 is isopropene, not combined with benzene, isopropene or R3； R830808 is cyclopentadiene, cyclopentadiene, isocyclopentadiene or isocyclopentadiene, none of which is associated with herrin
