Nkx3.2 fragment and pharmaceutical composition comprising same as active ingredient

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专利权人:

Ltd.;ICM Co.

发明人:

Kim, Dae-Won

申请号：

AU2020207879

公开号：

AU2020207879A1

申请日:

2020.07.24

申请国别(地区):

AU

年份:

2020

代理人:

摘要：

#$%^&*AU2020207879A120200813.pdf#####ABSTRACT The present invention relates to an Nkx3.2 fragment with improved stability under a histopathological environment of arthritis and to a pharmaceutical composition containing the same as an active ingredient. The Nkx3.2 fragment of the present invention has a function to activate NF-IB at the similar level to full-length Nkx3.2 and resistance to proteolysis by Siahl. In addition, the Nkx3.2 fragment exhibited at least a 10-fold improvement in degenerative arthritis treatment effect compared with Nkx3.2 in an animal model-based in vivo efficacy evaluation. Therefore, the Nkx3.2 fragment can be favorably used in the prevention or treatment of arthritis.

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