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FRAGMENT DE NKX3.2 ET COMPOSITION PHARMACEUTIQUE LE COMPRENANT EN TANT QUE PRINCIPE ACTIF
专利权人:
LTD.;ICM CO.
发明人:
KIM, DAE-WON
申请号:
CA3042186
公开号:
CA3042186A1
申请日:
2017.11.09
申请国别(地区):
CA
年份:
2018
代理人:
摘要:
The present invention relates to an Nkx3.2 fragment with improved stability under a histopathological environment of arthritis and to a pharmaceutical composition containing the same as an active ingredient. The Nkx3.2 fragment of the present invention has a function to activate NF-?B at the similar level to full-length Nkx3.2 and resistance to proteolysis by Siah1. In addition, the Nkx3.2 fragment exhibited at least a 10-fold improvement in degenerative arthritis treatment effect compared with Nkx3.2 in an animal model-based in vivo efficacy evaluation. Therefore, the Nkx3.2 fragment can be favorably used in the prevention or treatment of arthritis.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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