對抗人類介白素-２２（ＩＬ-２２）之抗體及其用途农业专利-农业学术服务平台

发明人:: LI, JING,李金,GILL, DAVINDER S.,吉尔　戴文德Ｓ.,吉爾　戴文德Ｓ.,VELDMAN, GEERTRUIDA M.,维德曼　吉楚达Ｍ.,維德曼　吉楚達Ｍ.,FOUSER, LYNETTE A.,佛瑟　莱纳特Ａ.,佛瑟　萊納特Ａ.,VALGE-ARCHER, VIIA,瓦吉　亚瑟　维亚,瓦吉　亞瑟　維亞,LOWE, DAVID C.,洛威　大卫Ｃ.,洛威　大衛Ｃ.,R,吉尔戴文德S.,吉爾戴文德S.,维德曼吉楚达M.,維德曼吉楚達M.,佛瑟莱纳特A.,佛瑟萊納特A.,瓦吉亚瑟维亚,瓦吉亞瑟維亞,洛威大卫C.,洛威大衛C.

摘要：: The present application provides human antibodies and antigen binding fragments thereof that specifically bind to the human interleukin-22 (IL-22). The antibodies can act as antagonists of IL-22 activity, thereby modulating immune responses in general, and those mediated by IL-22 in particular. The disclosed compositions and methods may be used for example, in diagnosing, treating or preventing inflammatory disorders, autoimmune diseases, allergies, septic shock, infectious disorders, transplant rejection, cancer, and other immune system disorders.本申請案提供可專一性結合至人類介百素－22(IL－22)之人類抗體及其抗原結合片段。該等抗體可作為IL－22活性之拮抗劑，藉以調節一般之免疫反應及特別為藉IL－22而媒介之免疫反應。所揭示組成物及方法可用於，例如診斷、治療或預防發炎性病症、自體免疫疾病、過敏、敗血性休克、感染性病症、移植排斥、癌症，及其它免疫系統病症。