Albert G. Thom;Ralph R. Minter;Davinder S. Gill;David C. Lowe;Geertruida M. Veldman;Caroline S. Russell;Suzanne E. Cohen;Lynette A. Fouser;Viia Valge-Archer;Jing Li
发明人:
Davinder S. Gill,Jing Li,Geertruida M. Veldman,Lynette A. Fouser,Viia Valge-Archer,David C. Lowe,Caroline S. Russell,Suzanne E. Cohen,Albert G. Thom,Ralph R. Minter
申请号：
US12474644
公开号：
US08187603B2
申请日:
2009.05.29
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present application provides human antibodies and antigen binding fragments thereof that specifically bind to the human interleukin-22 (IL-22). The antibodies can act as antagonists of IL-22 activity, thereby modulating immune responses in general, and those mediated by IL-22 in particular. The disclosed compositions and methods may be used for example, in diagnosing, treating or preventing inflammatory disorders, autoimmune diseases, allergies, septic shock, infectious disorders, transplant rejection, cancer, and other immune system disorders.
