Provided are monoclonal antibodies, antigen-binding fragments thereof, and combinations of the foregoing, that bind to, and inhibit the activity of, c-Met, and that are effective in treating cancers and other diseases, disorders, or conditions where pathogenesis is mediated by c-Met.本發明提供可與c-Met結合且抑制其活性,並有效治療由c-Met介導發病之癌症及其他疾病、病症或病狀的單株抗體,其抗原結合片段,及上述之組合。