GRINA, Jonas,SCHLACHTER, Stephen, T.,WALLACE, Eli, M.,YANG, Hanbiao,DIXON, Darryl David,JOSEY, John A.,RIZZI, James P.,WANG, Bin,WEHN, Paul,XU, Rui
申请号：
DK14842085
公开号：
DK3043784T3
申请日:
2014.09.05
申请国别(地区):
DK
年份:
2019
代理人:
摘要：
The present disclosure relates to HIF-2a inhibitors and methods of making and using them for treating cancer. Certain compounds were potent in HIF-2a scintillation proximity assay, luciferase assay, and VEGF ELISA assay, and led to tumor size reduction and regression in 786-O xenograft bearing mice in vivo.
