Dixon, Darryl David,Grina, Jonas,Josey, John A.,Rizzi, James P.,Schlachter, Stephen T.,Wallace, Eli M.,Wang, Bin,Wehn, Paul,Xu, Rui,Yang, Hanbiao
申请号：
AU2014318025
公开号：
AU2014318025A1
申请日:
2014.09.05
申请国别(地区):
AU
年份:
2016
代理人:
摘要：
The present disclosure relates to HIF-2α inhibitors and methods of making and using them for treating cancer. Certain compounds were potent in HIF-2α scintillation proximity assay, luciferase assay, and VEGF ELISA assay, and led to tumor size reduction and regression in 786-O xenograft bearing mice in vivo.
