Darryl David Dixon,Jonas Grina,John A. Josey,James P. Rizzi,Stephen T. Schlachter,Eli M. Wallace,Bin Wang,Paul Wehn,Rui Xu,Hanbiao Yang
申请号：
US16795697
公开号：
US20200190031A1
申请日:
2020.02.20
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present disclosure relates to HIF-2α inhibitors and methods of making and using them for treating cancer. Certain compounds were potent in HIF-2α scintillation proximity assay, luciferase assay, and VEGF ELISA assay, and led to tumor size reduction and regression in 786-O xenograft bearing mice in vivo.
