Roelof Hendrik Matthijs Kouwen,Pim Van Hee,Douwe Van Sinderen,Brian McDonnell,Jennifer Mahony
申请号：
US16025700
公开号：
US10519519B2
申请日:
2018.07.02
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Bacteriophage Insensitive Mutants (BIMs) of three Streptococcus thermophilus parent strains were generated and characterized for phage sensitivity, sedimentation rate, cell chain length, phage adsorption and CRISPR loci alterations. Several BIMs showed an altered sedimentation phenotype as well as an increase cell chain length, reduced phage sensitivity, reduced phage adsorption and 100% identity in three CRISPR loci. The results show that the derived BIMs have become phage-resistant through a mechanism other than CRISPR.
