作為ENaC阻斷劑之吡衍生物农业专利-农业学术服务平台

发明人:: BHALAY, GURDIP,巴哈雷　葛帝普,巴哈雷　葛帝普,EDWARDS, LEE,艾德华兹　里,艾德華茲　里,HOWSHAM, CATHERINE,豪夏　凯瑟琳,豪夏　凱瑟琳,HUNT, PETER,亨特　彼得,亨特　彼得,SMITH, NICHOLA,史密斯　尼可拉,史密斯　尼可拉

摘要：: Compounds of Formula I:and pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 have the meanings as indicated in the specification, are useful for treating diseases mediated by blockade of the epithelial sodium channel. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.式I化合物：及其醫藥學上可接受之鹽及溶劑合物，其中R1、R2、R3、R4、R5、R6、R7、R8、R9及R10具有如說明書中所指示之含義，適用於治療由阻斷上皮鈉通道所介導之疾病。亦描述含有該等化合物之醫藥組合物及製備該等化合物之製程。