KIM, Su Jin;KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY;한국생명공학연구원;김수진;MIN, Jeong Ki;고상석;민정기;KOH, Sang Seok
发明人:
KOH, Sang Seok,고상석,KIM, Su Jin,김수진,MIN, Jeong Ki,민정기
申请号：
KRKR2012/001858
公开号：
WO2012/128502A9
申请日:
2012.03.14
申请国别(地区):
KR
年份:
2013
代理人:
摘要：
The present invention relates to a composition for promoting vasculogenesis comprising PAUF, and more specifically relates to, by way of example, a pharmaceutical composition for chronic ulceration and protracted injury therapy and/or the treatment of cardiovascular disease using PAUF. The PAUF protein of the present invention exhibits an effect whereby the process of vasculogenesis can be induced by stimulating and thereby promoting growth, motility and differentiation of vascular endothelial cells. In other words, the PAUF protein having a novel function as a vasculogenesis promoting factor can be expected to be useful in the development of therapeutic agents for various diseases where vasculogenesis is required.Cette invention concerne une composition contenant le facteur PAUF et permettant de stimuler la vasculogenèse. L'invention concerne tout particulièrement, par exemple, une composition pharmaceutique contenant le facteur PAUF utilisée dans le traitement des lésions étendues et des ulcères chroniques et/ou le traitement de maladies cardiovasculaires. La protéine PAUF selon la présente invention a pour effet d'induire le processus de vasculogenèse en stimulant les cellules endothéliales vasculaires et en favorisant ainsi leur croissance, leur motilité et leur différenciation. Cette nouvelle fonction de stimulation de la vasculogenèse permet d'utiliser la protéine PAUF pour développer des agents thérapeutiques dans différentes maladies impliquant la vasculogenèse.본 발명은 PAUF를 포함하는 혈관신생 촉진용 조성물에 관한 것으로, 보다 구체적으로는 PAUF를 이용한 만성궤양, 지연성 상처치유 및/또는 심혈관계 질환의 치료용 약학적 조성물 등에 관한 것이다. 본 발명의 피에이유에프 단백질은 혈관내피세포를 자극하여 증식, 이동 및 분화를 촉진시킴으로서 혈관신생과정을 유도할 수 있는 효과를 보인다. 즉, 혈관신생촉진인자로서의 신규한 기능을 갖는 PAUF 단백질은 혈관 신생이 요구되는 다양한 질환의 치료제 개발에 유용하게 이용될 것으로 기대된다.
