TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION;VILLANOVA UNIVERSITY
发明人:
William WUEST,Kevin Patrick MINBIOLE
申请号：
US15034375
公开号：
US20160262384A1
申请日:
2014.11.05
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present disclosure provides an antimicrobial composition including a polycationic amphiphile compound, and the method of making and the method of using such a compound or composition. The compound having the formula (I) or (II) R1, R2, R3, R4, R5, R6, R10, or R11 is H or a C1-12 alkyl unsubstituted or optionally substituted with a functional group such as —OH, —OR′, —NH2, —NHR′, —NR′2, —N—C(0)R′, —N—C(0)CR′═CR′, —SH, —SR′, -0-C(0)R′, —C(0)R′, —CF3, —OCF3, halogen, benzyl, o-vinylbenzyl, m-vinylbenzyl, p-vinylbenzyl, phenyl, allyl, and substituted allyl. R7, R8 or R9 is a C1-12 alkyl unsubstituted or optionally substituted with a functional group such as —OH, —OR′, —NH2, —NHR′, —NR′2, —SH, —SR′, -0-C(0)R′, —C(0)R′, —CF3, and —OCF3. R′ is H or a C1-4 alkyl. X or Y is a halogen, m and n are integers in the range from 1 to 25.
