TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION;VILLANOVA UNIVERSITY
发明人:
William Wuest,Kevin Patrick Minbiole
申请号：
US15147219
公开号：
US10398142B2
申请日:
2016.05.05
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present disclosure provides an antimicrobial composition including a polycationic amphiphile compound, and the method of making and the method of using such a compound or composition. The compound having the formulaR1, R2, R3, R4, R5, R6, R10, or R11 is H or a C1-12 alkyl unsubstituted or optionally substituted with a functional group such as —；OH, —；OR′；, —；NH2, —；NHR′；, —；NR′；2, —；N—；C(O)R′；, —；N—；C(O)CR′；═；CR′；, —；SH, —；SR′；, —；O—；C(O)R′；, —；C(O)R′；, —；CF3, —；OCF3, halogen, benzyl, o-vinylbenzyl, m-vinylbenzyl, p-vinylbenzyl, phenyl, allyl, and substituted allyl. R7, R8 or R9 is a C1-12 alkyl unsubstituted or optionally substituted with a functional group such as —；OH, —；OR′；, —；NH2, —；NHR′；, —；SH, —；SR′；, —；O—；C(O)R′；, —；C(O)R′；, —；CF3, and —；OCF3. R′； is H or a C1-4 alkyl. X or Y is a halogen. m and n are integers in the range from 1 to 25.
