溶出が良好なイルベサルタン含有医薬組成物および口腔内崩壊錠
- 专利权人:
- 大日本住友製薬株式会社
- 发明人:
- 松岡 誠,森野 寛啓,村上 貴之,西井 宏行
- 申请号：
- JP2008217042
- 公开号：
- JP5296456B2
- 申请日:
- 2008.08.26
- 申请国别(地区):
- JP
- 年份:
- 2013
- 代理人:
- 摘要：
PROBLEM TO BE SOLVED: To provide an irbesartan-containing pharmaceutical composition which shows good elution property, and to provide an irbesartan-containing orally disintegrable tablet having excellent characteristics such that it (1) can be easily produced in a general facility without requiring any special formulation technology, (2) has a moderate strength for preventing disintegration during distribution, (3) shows rapid disintegration in oral cavity, (4) shows good elution property and (5) exerts good organoleptic properties at taking.
SOLUTION: The irbesartan-containing pharmaceutical composition contains at least one binder chosen from hydroxypropyl cellulose and polyvinyl alcohol. The orally disintegrable tablet contains (1) D-mannitol, (2) irbesartan, (3) at least one disintegrant chosen from crospovidon and carmellose, (4) at least one binder chosen from hydroxypropyl cellulose and polyvinyl alcohol and (5) at least one lubricant chosen from sodium stearyl fumarate and sucrose fatty acid ester.
COPYRIGHT: (C)2010,JPO&INPIT
- 来源网站：
- 中国工程科技知识中心
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