Refers to compounds derived from 4 - (3 - amino phenyl) - 5.6 - dihydro - 4H - [1,3] oxazin - 2 - ilaminas of formula (i) wherein R1 is H, alkyl or Halogen (C1 - C6) R2 is H, alkyl or Halogen (C1 - C6 alkyl () C1 - C3) R3 is H or alkyl (C1 - C6) R4 is Halogen, alkyl (C1 - C6) or Halogen alkoxy (C1 - C6) R5 is - C (= o) - R6 Where is heteroaryl R6 (C3 C6 cycloalkyl, optionally substituted or heterociclilo).Preferred compounds are: 3 - [(4R, 5R) - 5 - fluoro - 2 - amino - 4 - methyl - 5.6 - dihydro - 4H - [1,3] - oxazin - 4-yl) - 4 - Fluorine phenyl amide acid] - 5 - Chloro - - [2 - pyridine carboxylic acid 3 - [(4R, 5R) - 5 - fluoro - 2 - amino - 4 - methyl - 5.6 - dihydro - 4H - [1,3] - oxazin - 4-yl) - 4 - Fluorine phenyl amide acid] - 5 - cyano - pyridine - 2 - carboxylic acid Others. It also refers to a process of obtaining and to a Pharmaceutical composition.These compounds are inhibitors of BACE1 and BACE2 being useful in the treatment of Alzheimers disease, Type 2 diabetesSE REFIERE A COMPUESTOS DERIVADOS DE 4-(3-AMINO-FENIL)-5,6-DIHIDRO-4H-[1,3]OXAZIN-2-ILAMINAS DE FORMULA (I) DONDE R1 ES H, HALOGENO O ALQUILO(C1-C6) R2 ES H, ALQUILO(C1-C6) O HALOGENO-ALQUILO(C1-C3) R3 ES H O ALQUILO(C1-C6) R4 ES HALOGENO, ALQUILO(C1-C6) O HALOGENO-ALCOXI(C1-C6) R5 ES -C(=O)-R6, EN DONDE R6 ES HETEROARILO, CICLOALQUILO(C3-C6) O HETEROCICLILO OPCIONALMENTE SUSTITUIDOS. SON COMPUESTOS PREFERIDOS: [3-((4R,5R)-2-AMINO-5-FLUOR-4-METIL-5,6-DIHIDRO-4H-[1,3]-OXAZIN-4-IL)-4-FLUOR-FENIL]-AMIDA DEL ACIDO 5-CLORO-PIRIDINA-2-CARBOXILICO [3-((4R,5R)-2-AMINO-5-FLUOR-4-METIL-5,6-DIHIDRO-4H-[1,3]-OXAZIN-4-IL)-4-FLUOR-FENIL]-AMIDA DEL ACIDO 5-CIANO-PIRIDINA-2-CARBOXILICO ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCESO DE OBTENCION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE BACE1 Y BACE2 SIENDO UTILES EN EL TRATAMIENTO DE LA ENFERMEDAD DE ALZHEIMER, DIABETES TIPO 2
