The technology described herein relates to determination of fetal lung maturity, e.g. by noninvasive methods and methods of treatment and assays relating thereto. The present invention relates to markers and methods for the assessment of fetal lung maturity, for. determining the risk that a fetus will experience respiratory distress upon parturition, and for the monitoring the effects of maturity accelerating drugs on fetal lung maturity. More specifically, the present invention relates to markers of fetal lung maturity obtainable from maternal blood, and from amniotic fluid and neonatal lung aspirates.Linvention concerne la détermination de la maturité dun poumon fœtal, par exemple, par des procédés non invasifs, ainsi que des procédés de traitement et des essais associés.