Lamarche Martin G.,Perreault Jonathan,Miguez Carlos,Arbour Melanie,Choi Young Jun
申请号：
US201615566579
公开号：
US2018087024(A1)
申请日:
2016.04.15
申请国别(地区):
美国
年份:
2018
代理人:
摘要：
Described are genetically engineered C1-utilizing bacteria for the preparation of dicarboxylic acids, e.g. succinic acid. For instance, the bacteria comprise a mutation in a gene encoding a tricarboxylic acid cycle (TCA) succinate dehydrogenase (Sdh), preferably a mutation which inactivates or reduces Sdh's activity. Processes for the production of the modified bacteria as well as their use in the preparation of succinic acid on a C1-compound as carbon source are also discussed.
