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ANTIBACTERIAL COMPOUNDS AND BIOLOGICAL APPLICATIONS THEREOF
专利权人:
发明人:
Dmytro Atamanyuk,Vincent Gerusz,Francois Moreau,Vivien Henryon,Jerome Monbrun,Etienne Airiau
申请号:
US14438929
公开号:
US20150291636A1
申请日:
2013.10.28
申请国别(地区):
US
年份:
2015
代理人:
摘要:
The invention relates to compounds of formulae (Ia), (Ib) or (Ic) wherein, A1 and A2, identical or different, are H, (C1-C6) alkyl, (C1-C6) fluoroalkyl, (C2-C6) alkenyl, (C2-C6) alkynyl, (C1-C6) alkyl-ORa, (C1-C6) alkyl-SRa, (C1-C6) alkyl-NRaRb, ORa, SRa, NRaRb, or CORa A3 is H, OH or form a carbonyl with A4 A4 is H, OH or form a carbonyl with A3 A5 is H, CRaRbOH, F, OH or forms a double bond with X in the case where X is CH A6 is H or F X is CH2, CHF, CF2, CHOH, O, S, NRa or a simple bond, or X is CH in the case where A5 forms with X a double bond Y is P(O)(ORa)(ORb) or P(O)(ORa)(NRaRb) V is O or S A7 is H, (C1-C6) alkyl, (C1-C6) fluoroalkyl, (C2-C6) alkenyl, (C2-C6) alkynyl or (C1-C6) alkyl-ORa A8 is OH or H, Ra and Rb, identical or different, are H, (C1-C6) alkyl, (C1-C6) fluoroalkyl, (C1-C6) alkyl-OH or (C1-C6) alkyl-O—(C1-C6) alkyl and their addition salts thereof with acids and bases, their preparation and their use in the antibacterial prevention and therapy, used alone or in association with antibacterials, antivirulence agents or drugs reinforcing the host innate immunity.
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