Allan Svendsen;Lars Beier;Tanja Maria Rosenkilde Kjaer;Signe Eskildsen Larsen;Peter Colin Gregory;Thomas Lenhard
发明人:
Allan Svendsen,Lars Beier,Signe Eskildsen Larsen,Thomas Lenhard,Tanja Maria Rosenkilde Kjaer,Peter Colin Gregory
申请号：
US12745652
公开号：
US08455235B2
申请日:
2008.12.02
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The invention relates to novel variants of a protease derived from Nocardiopsis sp. (SEQ ID NO: 1) and closely related proteases, as well as their pharmaceutical use. The variants show improved performance in the treatment of pancreatic exocrine insufficiency (PEI). The variants may be combined with a lipase and/or an amylase. Other examples of medical indications are: Treatment of digestive disorders, pancreatitis, cystic fibrosis, diabetes type I, and/or diabetes type II.
