ALLAN SVENDSEN,LARS BEIER,SIGNE ESKILDSEN LARSEN,THOMAS LENHARD,TANJA MARIA ROSENKILDE KJAER,PETER COLIN GREGORY
申请号：
BRPI0819662
公开号：
BRPI0819662A2
申请日:
2008.12.02
申请国别(地区):
BR
年份:
2015
代理人:
摘要：
The invention relates to novel variants of a protease derived from Nocardiopsis sp. (SEQ ID NO: 1) and closely related proteases, as well as their pharmaceutical use. The variants show improved performance in the treatment of pancreatic exocrine insufficiency (PEI). The variants may be combined with a lipase and/or an amylase. Other examples of medical indications are: Treatment of digestive disorders, pancreatitis, cystic fibrosis, diabetes type I, and/or diabetes type II.
