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Polymer conjugate of hexa-coordinated platinum complex
专利权人:
Nippon Kayaku Kabushiki Kaisha
发明人:
Nakamura, Masaharu,Fukuda, Tsuyoshi,Kikuchi, Yusaku,Watanabe, Chihiro
申请号:
AU2016324370
公开号:
AU2016324370A1
申请日:
2016.09.08
申请国别(地区):
AU
年份:
2018
代理人:
摘要:
A drug delivery system (DDS) preparation of a platinum complex which selectively releases a highly active platinum complex in cells in reductive conditions, and exhibits the required high antitumour activity as a drug is yet to be obtained, and thus a novel DDS preparation of a platinum complex which can be used clinically is in demand. Accordingly, a polymer conjugate of a hexa-coordinated platinum complex is provided in which the hexa-coordinated platinum complex, which has halogens and hydroxyl groups at axial positions, is bonded directly or via spacers to side-chain carboxyl groups of a block copolymer having a polyethylene glycol structure moiety and a polyaspartic acid moiety or a polyglutamic acid moiety.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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