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CONJUGUÉ POLYMÈRE DE COMPLEXE DE PLATINE HEXACOORDONNÉ
专利权人:
Nippon Kayaku Kabushiki Kaisha
发明人:
申请号:
EP16846368.5
公开号:
EP3351580A1
申请日:
2016.09.08
申请国别(地区):
EP
年份:
2018
代理人:
摘要:
A DDS preparation of a platinum complex, which selectively releases a highly active platinum complex in cells that are under reducing conditions, and exhibits high antitumor activity that is required from a medicine, is still not available, and there is a demand for a novel DDS preparation of a platinum complex that may be used in clinical fields. There is provided a polymer conjugate of a hexa-coordinated platinum complex, the polymer conjugate comprising a block copolymer having a polyethylene glycol structural moiety and a polyaspartic acid moiety or a polyglutamic acid moiety; and a hexa-coordinated platinum complex having a halogen atom and a hydroxyl group at the axial positions, the hexa-coordinated platinum complex being bonded, directly or via a spacer, to a side-chain carboxyl group of the block copolymer.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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