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Long-lived gadolinium based tumor targeted imaging and therapy agents
专利权人:
WISCONSIN ALUMNI RESEARCH FOUNDATION
发明人:
申请号:
IL25912118
公开号:
IL259121D0
申请日:
2018.05.03
申请国别(地区):
IL
年份:
2018
代理人:
摘要:
or a salt thereof. R1 includes a chelating agent that is chelated to a gadolinium atom a is 0 or 1 n is an integer from 12 to 30 m is 0 or 1 Y is —H, —OH, —COOH, —COOX, —OCOX, or —OX, wherein X is an alkyl or an arylalkyl R2 is —N+H3, —N+H2Z, —N+HZ2, or —N+Z3, wherein each Z is independently an alkyl or an aroalkyl and b is 1 or 2. The compounds can be used to detect solid tumors or to treat solid tumors. In detection/imaging applications, the gadolinium emits signals that are detectable using magnetic resonance imaging. In therapeutic treatment, the gadolinium emits tumor-targeting charged particles when exposed to epithermal neutrons.
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