PROBLEM TO BE SOLVED: To provide a method of producing a solid dispersion having improved leachability of a poorly soluble medicine or the like.SOLUTION: A method of producing a solid dispersion comprises a step of (1) subjecting a nuclear material comprising spherical silicon dioxide, having an average particle diameter of 50 μm or more, and having a specific surface area of 100 m2/g or more, to a fluid bed coating with an active ingredient containing liquid, or (2) mixing an active ingredient with the nuclear material for heat melting.COPYRIGHT: (C)2015,JPO&INPIT【課題】難溶性薬物等の溶出性を改善させた固体分散体の製造方法を提供すること。【解決手段】球状二酸化ケイ素からなり、平均粒子径が50μm以上であり、及び比表面積が100m2/g以上である核物質に対し、(1)有効成分含有液により流動層コーティングを行う工程、又は、(2)有効成分を混合し、加熱溶融を行う工程、を含む、固体分散体の製造方法。【選択図】なし
