KUHNERT, SVEN,BAHRENBERG, GREGOR,MERLA, BEATRIX,SCHIENE, KLAUS,SCHRODER, WOLFGANG
申请号：
PE0011412011
公开号：
PE00762012A1
申请日:
2009.12.16
申请国别(地区):
PE
年份:
2012
代理人:
摘要：
Refers to a tetrahidroisoquinolinil - 4 - oxobutirico amide acid of formula (1): R1 is alkyl or Halogen, C1 - C10 heteroalquilo C2 C10, among others R2 is alkyl or Halogen, C1 - 10 together with R1 and the carbon Atom C3 - 7 a cycloalkyl or heterociclilo R3, R4, R5 and R6 are Each Hal Ogeno, NO2, CN, CF3, among others R7, R8, R9 and R10 are each Halogen, alkyl of C1 - C10Among others, R11 is Halo, CN, among others R12 is C1 - C10 alkyl, Halo, among others R13 is Halo, CN, C2 C10 alkyl or heteroalquilo, among others, R14 is Halo, CN, C1 - C10 alkyl or cycloalkyl with R11 and R13 or a heterociclilo C3 - C7 among others R15 is C1 - C10 alkyl heteroalquilo C1, C2 0cicloalquilo C3 - C7, among others.Preferred compounds are: acid 4-oxo-4 - (1 - phenyl - 2 - 3.4 - dihidroisoquinolin (H) - yl) - N - (3 - (trifluoromethyl) benzyl) butyric acid amide n - Benzyl - 4 - (5,7-dimethyl - 1 - phenyl - 3,4-dihydro - 1H - isoquinolin - 2 - il) - 4 - oxobutirico among others. Also referred to a Pharmaceutical composition. These compounds are modulators of KCNQ2 \/ 3 utilesen Pain TherapySE REFIERE A UN ACIDO TETRAHIDROISOQUINOLINIL-4-OXOBUTIRICO AMIDA DE FORMULA (1) DONDE: R1 ES HALOGENO, ALQUILO C1-C10 O HETEROALQUILO C2-C10, ENTRE OTROS R2 ES HALOGENO, ALQUILO C1-10 O FORMA JUNTO CON R1 Y EL ATOMO DE CARBONO UN CICLOALQUILO C3-7 O HETEROCICLILO R3, R4, R5 Y R6 SON CADA UNO HALOGENO, NO2, CF3, CN, ENTRE OTROS R7, R8, R9 Y R10 SON CADA UNO HALOGENO, ALQUILO C1-C10, ENTRE OTROS R11 ES HALO, CN, ENTRE OTROS R12 ES HALO, ALQUILO C1-C10, ENTRE OTROS R13 ES HALO, CN, ALQUILO O HETEROALQUILO C2-C10, ENTRE OTROS R14 ES HALO, CN, ALQUILO C1-C10 O FORMA JUNTO A R11 Y R13 UN CICLOALQUILO O HETEROCICLILO C3-C7, ENTRE OTROS R15 ES ALQUILO C1-C10, HETEROALQUILO C2-C10CICLOALQUILO C3-C7, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: ACIDO 4-OXO-4-(1-FENIL-3,4-DIHIDROISOQUINOLIN-2(H)-IL)-N-(3-(TRIFLUOROMETIL)BENZIL)BUTIRICO AMIDA ACIDO N-BENZIL-4-(5,7-DIMETIL-1-FENIL-3,4-DIHIDRO-1H-ISOQUINOLIN-2-IL)-4-OXO
