BOCK Dominique Anna,MAIER Thomas,HAFERKAMP Sven,PORSTMANN Frank
申请号：
US201515118119
公开号：
US2017166516(A1)
申请日:
2015.02.10
申请国别(地区):
美国
年份:
2017
代理人:
摘要：
The present disclosure relates to Tapentadol Hydrochloride in the polymorphic crystalline Form B, which is substantially free of polymorphic Form A as well as essentially free of low alkyl carboxylic acids or esters of such acids. Furthermore, the present disclosure provides a process to produce this polymorphic Form B substantially free of Form A and its preparation and use for pharmaceutical compositions. This process as well as the specific crystalline form is uncommon, improved and industrially advantageous. Furthermore, the disclosure relates to pharmaceutical compositions and uses thereof.
