DAN PETERS,ELSEBET ØSTERGAARD NIELSEN,JOHN PAUL REDROBE
申请号：
BRPI0907991
公开号：
BRPI0907991A2
申请日:
2009.02.27
申请国别(地区):
BR
年份:
2015
代理人:
摘要：
This invention relates to novel 4-benzhydryloxy-tetraalkyl-piperidine derivatives of Formula (I), any of its stereoisomers or any mixture of its stereoisomers, or an N-oxide thereof, or a pharmaceutically acceptable salt thereof, wherein Ra represents hydrogen or C1-6-alkyl； Rb and Rc independent of each other represent a phenyl group, which phenyl group is optionally substituted with one or more substituents independently selected from the group consisting of halo, trifluoromethyl, trifluoromethoxy, cyano, C1-6-alkoxy and methylenedioxo； R&prime；, R&Prime；, R&prime；&Prime； and R&Prime；&Prime； independent of each other represent C1-6-alkyl； and with the proviso that the compound is not 4-benzhydryloxy-1,2,2,6,6-pentamethyl-piperidine, useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
