INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property - Organization International Bureau irst0) (43) International Publication Date .... ....r .....) 8 June 2017 (08.06.2017) WI P0 I P CT ID Hit (10) WO International 2017/096230 1111111111111111111111111111111111111111111111111111111111111t111111111111111 Publication Number Al (51) International Patent Classification: Jamie Court, Suite 101, South San Francisco, CA 94080 A61K 31/4439 (2006.01) A61P 35/02 (2006.01) (US). HUTCHALEELAHA, Athiwat c/o Global Blood A61K 9/48 (2006.01) Therapeutics. Inc., 400 East Jamie Court, Suite 101, South San Francisco, CA 94080 (US). (21) International Application Number: PCT/US2016/064723 (74) Agents: CAMPBELL, A. Patricia et al. Jones Day, 250 Vesey Street, New York, NY 10281-1047 (US). (22) International Filing Date: 2 December 2016 (02.12.2016) (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, (25) Filing Language: English AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (26) Publication Language: English BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (30) Priority Data: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, 62/263,554 4 December 2015 (04.12.2015) US KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, 62/375,832 16 August 2016 (16.08.2016) US MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (71) Applicant: GLOBAL BLOOD THERAPEUTICS, INC. OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, [US/US] 400 East Jamie Court, Suite 101, South San SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, Francisco, CA 94080 (US). TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (72) Inventors: RAMOS, Eleanor, L. c/o Global Blood Therapeutics. Inc., 400 East Jamie Court, Suite 101, South (84) Designated States (unless otherwise indicated, for every San Francisco, CA 94080 (US). LEHRER-GRAIWER, kind of