BELL, John C.,LE BOEUF, Fabrice,HUH, Michael S.,TANG, Matthew Y.,KELLER, Brian Andrew,PELIN, Adrian
申请号：
AU2019205037
公开号：
AU2019205037A1
申请日:
2019.01.04
申请国别(地区):
AU
年份:
2020
代理人:
摘要：
The disclosure relates to modified vaccinia virus vectors derived from the Copenhagen strain of vaccinia virus, as well as methods of using the same for the treatment of various cancers. The disclosure provides modified Copenhagen-derived vaccinia virus vectors that exhibit various beneficial therapeutic activities, including enhanced oncolytic activity, spread of infection, immune evasion, tumor persistence, capacity for incorporation of exogenous DNA sequences, amenability for large scale manufacturing, and safety.
