Mitchell H. FINER,Lorena LERNER,Christophe QUÉVA,Edward KENNEDY
申请号：
US16633653
公开号：
US20200206285A1
申请日:
2018.07.26
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present disclosure relates to recombinant viral vectors for the treatment and prevention of cancer. Oncolytic viral vectors incorporate one or more of the following features: viral replication restriction by insertion of microRNA (miRNA) target sequences into the viral genome； disruption of oncogenic miRNA function； cancer microenvironment remodeling； and cancer cell targeting by incorporation of protease-activated antibodies into the viral particle.
