Viral vectors whose replication and, optionally, passenger gene are controlled by a gene switch activated by heat in the presence or absence of a small-molecule regulator

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专利权人:

Richard Voellmy

发明人:

Richard Voellmy

申请号：

US12929553

公开号：

US08137947B2

申请日:

2011.02.01

申请国别(地区):

US

年份:

2012

代理人:

摘要：

The present invention relates to conditionally replicating viruses or pairs of viruses containing a gene switch that is activatable by transient heat or other proteotoxic stress in the presence or absence of a small molecule regulator. The gene switch controls the expression of a gene for a protein required for efficient viral replication and may also control the activity of a passenger gene.

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