TIMOTHY PIETRO SUREN PERERA,MICHEL MARIE FRANCOIS JANICOT,THEO FRANS MEERT,EDDY JEAN EDGARD FREYNE
申请号：
BRPI0718021
公开号：
BRPI0718021A2
申请日:
2007.10.25
申请国别(地区):
BR
年份:
2013
代理人:
摘要：
The present invention is concerned with the finding that the macrocyclic quinazoline derivative 4,6-ethanediylidenepyrimido[4,5-b][6,1,12]benzoxadiazacyclo-pentadecine, 17-bromo-8,9,10,11,12,13, 14,19-octahydro-20-methoxy-13-methyl-, described as compound 22 in PCT publication WO2004/105765, is useful in the manufacture of a medicament for the treatment or prevention of bone cancers and methods for killing bone cancer cells, including osteosarcomas, chondrosarcomas, myeloma bone disease and osteolytic bone metastases from other primary sites. It accordingly provides methods for treating, preventing, delaying or mitigating bone cancer, or for preventing and treating of bone loss associated with cancer metastases.
