PROBLEM TO BE SOLVED: To provide a novel drug for the treatment of multiple myeloma.SOLUTION: The invention provides a myeloma cell death inducer containing palmitic acid, and a pharmaceutical composition for the treatment of myeloma containing this as an active ingredient. The pharmaceutical composition according to the invention may contain one or more components selected from the group consisting of a proteasome inhibitor, an SCD-1 inhibitor, an HDAC inhibitor, an immunomodulator, an antibody drug, a steroid, and an anticancer agent as an active ingredient. The myeloma cell death inducer and the pharmaceutical composition for the treatment of myeloma according to the invention extend the options of the treatment of multiple myeloma, and cause improvement in the therapeutic effect by multidrug combination therapy.COPYRIGHT: (C)2015,JPO&INPIT【課題】多発性骨髄腫の治療のための新規な薬剤の提供。【解決手段】パルミチン酸を含有する骨髄腫細胞死誘導剤と、これを有効成分として含有する骨髄腫治療用医薬組成物と、を提供する。本発明に係る医薬組成物は、プロテアソーム阻害剤、SCD-1阻害剤、HDAC阻害剤、免疫調節薬、抗体医薬、ステロイド剤及び抗癌剤からなる群から選択される一以上を有効成分として含有していてもよい。本発明に係る骨髄腫細胞死誘導剤及び骨髄腫治療用医薬組成物は、多発性骨髄腫の治療の選択肢を広げ、多剤併用による治療効果の向上をもたらす。【選択図】なし
