The present invention relates to an azaaryl derivative having CSF-1R inhibitory activity, a method for producing the same, and an application thereof. The series of compounds according to the invention have the structure of formula (I) below, the definition of each substituent being as described in the description and the claims. A series of compounds according to the present invention include drugs for treating cancer, tumors, autoimmune diseases, metabolic or metastatic diseases, especially ovarian cancer, pancreatic cancer, prostate cancer, breast cancer, cervical cancer, glioblastoma, multiple bone marrow. It is widely applicable to the manufacture of drugs for treating tumors, metabolic diseases, neurodegenerative diseases, metastases of primary tumor sites or bone metastatic cancer, and is expected to be developed as a new generation CSF-1R inhibitor drug. There is. [Chemical 1]本発明はCSF-1R阻害活性を有するアザアリール誘導体、その製造方法および応用に関するものである。本発明による一連の化合物は下記式(I)の構造を有し、各置換基の定義は明細書と請求の範囲に記載の通りである。本発明による一連の化合物は癌、腫瘍、自己免疫疾患、代謝性疾患または転移性疾患を治療する薬物、特に卵巣癌、膵臓癌、前立腺癌、乳癌、子宮頸癌、膠芽腫、多発性骨髄腫、代謝性疾患、神経変性疾患、原発性腫瘍部位の転移または骨転移性癌を治療する薬物の製造に広く応用でき、新世代のCSF-1R阻害剤薬物として開発されることが期待されている。 【化１】
