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ANTI-INFLAMMATORY AGENTS
专利权人:
CAMBRIDGE ENTERPRISE LIMITED
发明人:
GRAINGER, DAVID JOHN,FOX, DAVID JOHN
申请号:
HK08105881.3
公开号:
HK1111094B
申请日:
2008.05.27
申请国别(地区):
HK
年份:
2015
代理人:
摘要:
The invention provides compounds, pharmaceutical compositions and uses of compounds of general formula (I) or a pharmaceutically acceptable salt thereof, for the preparation of a medicament intended to treat an inflammatory disorder wherein z is 1, 2 or 4 X is -CO-Yk-(R1)n or SO2-Yk-(R1)n k is 0 or 1 Y is a cycloalkyl or polycyloalkyl group (such as an adamantyl, adamantanemethyl, bicyclooctyl, cyclohexyl, cyclopropyl group) or is a cycloalkenyl or polycycloalkenyl group each R1 is independently selected from hydrogen or an alkyl, haloalkyl, alkoxy, haloalkoxy, alkenyl, alkynyl or alkylamino radical of 1 to 20 carbon atoms (for example of 5 to 20 carbon atoms, of 8 to 20 carbon atoms, of 9 to 20 carbon atoms, of 10 to 18 carbon atoms, of 12 to 18 carbon atoms, of 13 to 18 carbon atoms, of 14 to 18 carbon atoms, of 13 to 17 carbon atoms) or each R1 is independently selected from fluoro, chloro, bromo, iodo, hydroxy, oxyalkyl, amino, aminoalkyl or aminodialkyl radical and n is any integer from 1 to m, where m is the maximum number of substitutions permissible on the cyclo-group Y (such that n=1 if k=0, such that the R1 group is bonded directly to the carbonyl or sulfonyl group) provided that simultaneously X cannot be an undec-10-en-l-oyl group and z be equal to 1 or 2 or alternatively R1 is selected from a peptido radical having from 1 to 4 peptidic moieties linked together by peptide bonds.Linvention concerne des composés, des compositions pharmaceutiques et des utilisations des composés de la formule générale (I), ou un sel pharmaceutiquement acceptable de ces derniers, dans la préparation dun médicament destiné à traiter un trouble inflammatoire, où z est 1, 2 ou 4 X est -CO-Yk-(R1)n ou SO2-Yk-(R1)n k est 0 ou 1 Y est un groupe cycloalkyle ou polycyloalkyle (par exemple un groupe adamantyle, adamantaneméthyle, bicyclooctyle, cyclohexyle, cyclopropyle) ou est un groupe cycloalcényle ou polycycloalcényle chaque R1 est choisi indépendamment entre lhydrogène ou un rad
来源网站:
中国工程科技知识中心
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http://www.ckcest.cn/home/

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