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LIBERATION CONTROLEE D'AGENTS ACTIFS DANS LA PEAU
专利权人:
RUTGERS; THE STATE UNIVERSITY OF NEW JERSEY
发明人:
KOHN, JOACHIM B.,MICHNIAK, BOZENA,DEVORE, DAVID,SHEIHET, LARISA,CHANDRA, PRAFULLA,BATHEJA, PRIYA
申请号:
CA2676841
公开号:
CA2676841C
申请日:
2008.01.31
申请国别(地区):
CA
年份:
2017
代理人:
摘要:
Topical compositions are provided in which active compounds for topical delivery through the stratum corneum are complexed with nanospheres of a triblock copolymer having an A-B-A structure wherein each A end block is a water-soluble, hydrophilic and non-toxic polymer or oligomer; and the hydrophobic middle B block is a hydrophobic polymer or oligomer with the same or different repeating units having the structure according to formula:(I) wherein X is - C - R - C - or - C -; Z is between 2 and about 100, inclusive; R1 is CH=CH or (CH2),, wherein n is from 0 to 18, inclusive; R2 is selected from hydrogen and straight and branched alkyl, alkoxy, alkylaryl and alkoxyaryl groups containing up to 18 carbon atoms; and R is selected from a bond or straight and branched alkyl, alkoxy, alkylaryl and alkoxyaryl groups containing up to 18 carbon atoms.
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