Joachim Kohn,Bozena Michniak,David Devore,Larisa Sheihet,Prafulla Chandra,Priya Batheja
申请号：
US12525529
公开号：
US08414871B2
申请日:
2008.01.31
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Topical compositions are provided in which active compounds for topical delivery through the stratum corneum are complexed with nanospheres of a triblock copolymer having an A-B-A structure wherein each A end block is a water-soluble, hydrophilic and non-toxic polymer or oligomer； and the hydrophobic middle B block is a hydrophobic polymer or oligomer with the same or different repeating units having the structure according to formula:(I) wherein X is —C—R—C— or —C—； Z is between 2 and about 100, inclusive； R1 is CH═CH or (CH2), wherein n is from 0 to 18, inclusive； R2 is selected from hydrogen and straight and branched alkyl, alkoxy, alkylaryl and alkoxyaryl groups containing up to 18 carbon atoms； and R is selected from a bond or straight and branched alkyl, alkoxy, alkylaryl and alkoxyaryl groups containing up to 18 carbon atoms.
