NATIONAL CENTER OF NEUROLOGY AND PSYCHIATRY;学校法人北里研究所;国立大学法人筑波大学;NIPPON CHEMIPHAR CO., LTD.;UNIVERSITY OF TSUKUBA;THE KITASATO INSTITUTE;日本ケミファ株式会社;国立研究開発法人国立精神・神経医療研究センター
According to the present invention, a compound represented by general formula (I), a tautomer, stereoisomer or pharmaceutically acceptable salt of the compound, or a solvate of the compound, the tautomer, the stereoisomer or the pharmaceutically acceptable salt is used as antianxiety agent, an antidepressant agent or the like.(In the formula, R1 represents a hydrogen atom, a C1-10 alkyl group, a cycloalkyl alkyl group wherein a cycloalkyl moiety has 3-6 carbon atoms and an alkylene moiety has 1-5 carbon atoms, or the like； R2 represents a 4-7 membered saturated heterocyclic ring that contains, as ring atoms, two or more carbon atoms and one or two heteroatoms which may be the same or different and are selected from among N, O and S； the heterocyclic ring may be substituted by an oxo group or another substituent； R2 is bonded to Y via a carbon atom that is a ring atom of R2； R3, R4 and R5 may be the same or different, and each represents a hydrogen atom, a hydroxy group or the like； R6a and R6b may be the same or different, and each represents a hydrogen atom or the like； R7 and R8 may be the same or different, and each represents a hydrogen atom or the like； R9 and R10 may be the same or different, and each represents a hydrogen atom or the like； X represents O or CH2； and Y represents C(=O) or the like.)Selon la présente invention, un composé représenté par la formule générale (I), un tautomère, un stéréoisomère ou un sel pharmaceutiquement acceptable du composé, ou un solvate du composé, du tautomère, du stéréoisomère ou du sel pharmaceutiquement acceptable est utilisé en tant qu'agent anxiolytique, antidépresseur ou analogue. (Dans la formule, R 1 représente un atome d'hydrogène, un groupe C 1-10 alkyle, un groupe cycloalkyle alkyle dans lequel une fraction cycloalkyle a de 3 à 6 atomes de carbone et une fraction alkylène a de 1 à 5 atomes de carbone, ou analogue； R 2 représente un cycle hétérocyclique saturé de 4-7 éléments qui contient, en tant qu'atome
