KOWARIK, MICHAEL T.,WETTER, MICHAEL L.,KEMMLER, STEFAN J.,HAUPTLE, MICHA A.,GAMBILLARA, VERONICA,MALLY, MANUELA
申请号：
CA2940547
公开号：
CA2940547A1
申请日:
2015.02.23
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
Provided herein is a novel E. coli O polysaccharide, O25B. Also provided herein are prokaryotic host cells comprising enzymes (e.g., glycosyltransferases) used in O25B production. The host cells provided herein produce 025B bioconjugates, wherein said bioconjugates comprise O25B linked to a carrier protein. Further provided herein are compositions, e.g., pharmaceutical compositions, comprising O25B and/or bioconjugates comprising O25B. Such compositions can be used as vaccines against infection with ExPEC, and may further comprise one or more additional bioconjugates.
