A method is described for setting the detection of a macropixel signal of an x-ray detector with a plurality of pixels, each combined to form at least one macropixel. The geometrical efficiency and the signal drift factor of the individual pixels are first established. A target drift value is established. A parameter, which sets a compromise between an allowed drift of the macropixel signals and the achievable dose efficiency, is also defined. Based on the established parameters, the weighting of the individual pixel signals, taking into account a function taking account of the signal drift and the dose utilization of the resulting macropixel signal depending on the weightings of the pixel signals, is established. A weighted addition of the individual pixel signals to form macropixel signals is defined on the basis of the weightings. A signal detection device, an x-ray detector and a computed tomography system are also described.
