您的位置: 首页 > 农业专利 > 详情页

СПОСОБ И ПРОМЕЖУТОЧНЫЕ СОЕДИНЕНИЯ ДЛЯ ПОЛУЧЕНИЯ МАКРОЛАКТАМОВ
专利权人:
МЕРК ШАРП И ДОУМ КОРП.
发明人:
СЮЙ Фэн,ХАМФРИ Гай,ПЭЙ Тао,СУН Чжиго Джейк,ВАН Тао,АРТИНО Лаура
申请号:
RU2014110400
公开号:
RU2014110400A
申请日:
2012.08.16
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. A process for producing a compound or a salt thereof: comprising condensation step to compound its salt with soedineniemili salt thereof, wherein the condensation comprises the use of a condensing agent and a pyridine or pyridine proizvodnogo.2. A method according to Claim. 1, wherein said condensing agent is EDC, and the method comprises the use of at least 10 equivalents of pyridine and atsetonitrila.3. A method according to Claim. 1, wherein said condensing agent is EDC, and the method includes the use of THF-DMAc or THF and temperatures range from -10 ° C to 50 ° C.4. A compound having the structure of formula I or a salt thereof: wherein R1 represents a leaving group, or, with the proviso that if R is a leaving group, then R is H and when R is the structure I, then R is H and R is OH, or R Rsoedineny together to form a covalent bond or R is Ci ^ alkyl or aryl iRpredstavlyaet or a Ci ^ alkyl or Ctsikloalkil.5. . A compound according to claim 4, wherein said compound is selected from the group consisting of: or their soli.6. The compound of claim. 5, wherein said compound predstavlyaetsoboy MeCN solvate of the methanesulfonate salt and the compound 14, wherein said solvate is characterized by a powder X-ray diffraction pattern obtained using copper Kizluchenie which comprises 2θ values ​​in degrees of about 5.3, 12.0 and 14.7. A process for preparing a compound according to claim 4, comprising the step of:., Where 14A, 15A and 16A may be provided in the form soli.8. A process for preparing a compound according to claim 6, comprising the step of:., Where the compounds 14, 15 and 16 may be provided as soli.9. A process for preparing a compound according to claim 6, comprising the steps:., Where the compounds 14, 15, 16 and 17 may be provided1. Способ получения соединения A или его соли:,включающий стадию конденсации соединенияили его соли с соединениемили его солью, где конденсация включает применение конденсирующего агента и пиридина или пиридинового производно
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充